SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Demopulos Gregory A MD (Last) (First) (Middle) 1420 FIFTH AVENUE, SUITE 2600 (Street) SEATTLE WA 98101-2347 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 10/07/2009	3. Issuer Name and Ticker or Trading Symbol OMEROS CORP [ OMER ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director X 10% Owner X Officer (give title below) Other (specify below) See General Remarks	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	1,475,280	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Employee Stock Option (right to buy)	(1)	12/10/2011	Common Stock	1,542	$0.52	D
Employee Stock Option (right to buy)	(2)	12/12/2016	Common Stock	612,244	$0.98	D
Employee Stock Option (right to buy)	(2)	12/12/2016	Common Stock	408,163	$0.98	D
Employee Stock Options (right to buy)	(3)	12/30/2017	Common Stock	102,040	$2.45	D

Explanation of Responses:

1. The option, representing the right to purchase a total of 47,511 shares, became fully exercisable on December 11, 2001, the date of grant.

2. The option is exercisable in 48 equal monthly installments. The first installment became exercisable on March 28, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

3. The option became exercisable as to 25,510 shares on December 30, 2008, and thereafter becomes exercisable each monthly anniversary thereafter at the rate of 1/48 of the total shares.

Remarks:

President, Chief Executive Officer, Chief Medical Officer, Chairman of the Board

	/s/ Alex F. Sutter, attorney-in-fact on behalf of Gregory A. Demopulos	10/07/2009
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
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