EX-4.3 8 a2131592zex-4_3.htm EXHIBIT 4.3
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Exhibit 4.3

AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

        THIS AMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the "Amendment") is made and entered into as of this            day of April, 2004, by and among FAVRILLE, INC., a Delaware corporation (the "Company"), and the investors listed on Schedule A attached hereto (each of which is referred to herein as an "Investor" and all of which are collectively referred to herein as the "Investors").


RECITALS

        WHEREAS, concurrently herewith, the Company and certain of the Investors have entered into that certain Amendment No. 1 to Series C Preferred Stock Purchase Agreement (the "Purchase Amendment") pursuant to which the Company is selling and issuing, and the New Investors (as defined in the Purchase Amendment) are purchasing, an aggregate of                        shares of the Company's Series C Preferred Stock, par value $0.001 per share (the "Additional Shares");

        WHEREAS, the Company and the Investors (other than the New Investors) are parties to that certain Amended and Restated Investor Rights Agreement dated March 26, 2004 (the "Investor Rights Agreement"). Any capitalized term used in this Amendment and not defined herein shall have the meaning assigned to such term in the Investor Rights Agreement;

        WHEREAS, Section 3.7 of the Investor Rights Agreement provides that the Investor Rights Agreement may be amended only with the written consent of (i) the Company, (ii) the holders of a majority of the Registrable Securities then outstanding, (iii) the holders of 662/3% of the Series A Stock then outstanding, (iv) the holders of 662/3% of the Series B Stock and the Series B-2 Stock then outstanding, voting together as a single class, and (v) the holders of 51% of the Series C Stock then outstanding; and

        WHEREAS, in connection with the consummation of the transactions contemplated by the Purchase Amendment, the parties to the Investor Rights Agreement wish to amend the Investor Rights Agreement to cause each of the New Investors to become a party to the Investor Rights Agreement.


AGREEMENT

        NOW THEREFORE, in consideration of the foregoing promises and the mutual covenants set forth herein, the Company and the Investors agree as follows:

1.     AMENDMENT OF INVESTOR RIGHTS AGREEMENT.

        (a)   Effective as of the Second Closing Date (as defined in the Purchase Amendment), each of the New Investors shall become a party to the Investor Rights Agreement and shall be deemed both an "Investor" and a "Holder" for purposes of the Investor Rights Agreement, and the shares of Series C Stock purchased by such New Investors shall be deemed "Registrable Securities" for purposes of the Investor Rights Agreement.

        (b)   The Company and the Investors hereby agree that the provisions of Section 2.5 of the Investor Rights Agreement shall not apply to the offer or sale of the Additional Shares to the New Investors.

2.    COUNTERPARTS.    This Amendment may be executed in any number of counterparts, each of which shall be an original, but all of which together shall constitute one instrument.

3.    NO OTHER CHANGES.    Except as otherwise provided herein, all the terms and conditions of the Agreement which are not inconsistent herewith shall remain in full force and effect and shall apply equally to this Amendment.

[THE REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]

1

        IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENTas of the date set forth in the first paragraph hereof.

  FAVRILLE, INC.

 
By:
 
 
    /s/  JOHN P. LONGENECKER      
John P. Longenecker
President and Chief Executive Officer

 
Address:
10421 Pacific Center Court Suite 150 San Diego, CA 92121
  Fax: (858) 526-8000

 
INVESTORS:

 
WILLIAM BLAIR CAPITAL PARTNERS VII, L.P.

 
By:
William Blair Capital Management VII, L.P.
Its: General Partner

 
By:
William Blair Capital Management VII, L.L.C.
  Its: General Partner

 
By:
 
 
    /s/  A.M. MINOCHERHOMJEE      
  Name: Arda Minocherhomjee
  Its: Managing Director

 
Address:
227 West Monroe Street
Suite 3500
Chicago, Illinois 60606

 
Fax:
(312) 236-5782

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  WILLIAM BLAIR CAPITAL PARTNERS VII QP, L.P.

 
By:
William Blair Capital Management VII, L.P.
  Its: General Partner

 
By:
William Blair Capital Management VII, L.L.C.
  Its: General Partner

 
By:
 
 
    /s/  A.M. MINOCHERHOMJEE      
  Name: Arda Minocherhomjee
  Its: Managing Director

 
Address:
227 West Monroe Street
Suite 3500
Chicago, Illinois 60606
  Fax: (312) 236-5782

 
ALLOY PARTNERS 2000, L.P.
ALLOY VENTURES 2000, L.P.
ALLOY CORPORATE 2000, L.P.
ALLOY INVESTORS 2000, L.P.

 
By:
Alloy Ventures 2000, LLC
  Their: General Partner

 
/s/  DOUGLAS E. KELLY      
Managing Member of Alloy Ventures 2000, LLC

 
Address:
480 Cowpers Street
2nd Floor
Palo Alto, CA 94301
  Fax: (650) 687-5010

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  ALLOY ANNEX I, L.P.

 
By:
Alloy Annex I, LLC
  Its: General Partner

 
/s/  DOUGLAS E. KELLY      
Managing Member of Alloy Annex I, LLC

 
Address:
480 Cowpers Street, 2nd Floor
Palo Alto, CA 94301

 
DE NOVO VENTURES I, LP
DE NOVO (Q) VENTURES I, LP

 
By:
De Novo Management LLC
  Their: General Partner

 
/s/  FRED DOTZLER      
Fred Dotzler, Managing Director

 
Address:
1550 El Camino Real
Suite 150
Menlo Park, CA 94025
  Fax: (650) 329-1315

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  SANDERLING VENTURE PARTNERS V, L.P.
SANDERLING V BIOMEDICAL, L.P.
SANDERLING V LIMITED PARTNERSHIP
SANDERLING V BETEILIGUNGS GMBH & CO. KG
SANDERLING VENTURE PARTNERS V CO-INVESTMENT FUND, L.P.
SANDERLING V BIOMEDICAL CO-INVESTMENT FUND, L.P.

 
By:
Middleton, McNeil & Mills Associates V, LLC

 
/s/  FRED MIDDLETON      
Fred A. Middleton
Managing Director

 
Address:
400 South El Camino Real
Suite 1200
San Mateo, CA 94402
  Fax: (650) 375-7077

 
SANDERLING V VENTURES MANAGEMENT

 
/s/  FRED MIDDLETON      
Fred A. Middleton
Owner

 
Address:
400 South El Camino Real
Suite 1200
San Mateo, CA 94402
  Fax: (650) 375-7077

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  FORWARD VENTURES III INSTITUTIONAL PARTNERS L.P.

 
By:
Forward III Associates, LLC

 
By:
 
 
    /s/  IVOR ROYSTON      
  Name:    
    Ivor Royston, M.D.
  Title:    
    Managing Member

 
Address:
9393 Towne Centre Drive
Suite 200
San Diego, CA 92121
  Fax: (858) 452-8799

 
FORWARD VENTURES III L.P.

 
By:
Forward III Associates, LLC

 
By:
 
 
    /s/  IVOR ROYSTON      
  Name:    
    Ivor Royston, M.D.
  Title:    
    Managing Member

 
Address:
9393 Towne Centre Drive
Suite 200
San Diego, CA 92121
  Fax: (858) 452-8799

 
FORWARD VENTURES IV B L.P.

 
By:
Forward IV Associates, LLC

 
By:
 
 
    /s/  IVOR ROYSTON      
  Name:    
    Ivor Royston, M.D.
  Title:    
    Managing Member

 
Address:
9393 Towne Centre Drive
Suite 200
San Diego, CA 92121
  Fax: (858) 452-8799

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  FORWARD VENTURES IV L.P.

 
By:
Forward IV Associates, LLC

 
By:
 
 
    /s/  IVOR ROYSTON      
  Name:    
    Ivor Royston, M.D.
  Title:    
    Managing Member

 
Address:
9393 Towne Centre Drive
Suite 200
San Diego, CA 92121
  Fax: (858) 452-8799

 
JACOBS INVESTMENT COMPANY, LLC

 
By:
 
 
    /s/  GARY E. JACOBS      
  Name:    
    Gary E. Jacobs
  Title:    
    Manager

 
Address:
13974 Boquito Drive
Del Mar, CA 92014

 
STEPHEN J. KANDEL SSB ROTH CONVERSION IRA CUST.

 
By:
 
 
   
  Name: Stephen J. Kandel
  Title: Beneficial Owner

 
Address:
1021 Muirlands Drive
La Jolla, CA 92037

 
    
SANDEN KANDEL

 
Address:
1021 Muirlands Drive
La Jolla, CA 92037

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  EBR HOLDINGS II LTD.

 
By:
 
 
   
  Name:    
   
  Title:    
   

 
Address:
3366 N. Torrey Pines Ct.
Suite 210
La Jolla, CA 92037

 
    
ELLIOT FEUERSTEIN

 
Address:
8588 Ruette Monte Carlo
La Jolla, CA 92037

 
MICHAEL M. BERNS LIVING TRUST
DATED 10/16/90, MICHAEL M. BERNS,
TRUSTEE

 
By:
 
 
   
Michael M. Berns
Trustee

 
Address:
1617 Emerald Bay
Laguna Beach, CA 92651

 
THE PAYNE FAMILY TRUST DATED 1/23/85, ERROL G. PAYNE AND NAOMI F. PAYNE, TRUSTEES

 
By:
 
 
   
Errol G. Payne and Naomi F. Payne
Trustees

 
Address:
21 Ritz Cove Drive
Dana Point, CA 92629

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]


 
    
JOSHUA COHEN AND LITA COHEN

 
Address:
8010 Frost Street, Suite 408
San Diego, CA 92123

 
MICHAEL S. GROSSMAN UBS IRA ROLLOVER DG87091-68

 
By:
 
 
    /s/  MICHAEL S. GROSSMAN      
  Name: Michael S. Grossman
  Title: Owner

 
Address:
310 Forward Street
La Jolla, CA 92037

 
MARGARET GROSSMAN UBS IRA DG44753

 
By:
 
 
    /s/  MARGARET STEVENS GROSSMAN      
  Name: Margaret Grossman
  Title: Owner

 
Address:
310 Forward Street
La Jolla, CA 92037

 
    
GUILIO WASSMER

 
Address:
Schlyffistrasse 15
8806 Bäch
Switzerland

 
/s/  CHRISTOPH DIETSCHE      
CHRISTOPH DIETSCHE

 
Address:
Jurastrasse 27
CH-5000 Aarau
Switzerland

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  WARNKE BROADLEY KENNEDY FAMILY TRUST DATED 3/29/89, JOSEPH F. KENNEDY, TRUSTEE, GERIANN WARNKE, TRUSTEE

 
By:
 
 
    /s/  JOSEPH F. KENNEDY      
  Name: Joseph F. Kennedy
  Title Trustee

 
Address:
6390 Cardeno Drive
La Jolla, CA 92037

 
IRA M. LECHNER & WINIFRED EILEEN HAAG FAMILY TRUST DATED 1/21/00: IRA M. LECHNER & WINIFRED EILEEN HAAG TRUSTEES

 
By:
 
 
    /s/  IRA M. LECHNER      
  Name:    
    Ira M. Lechner
  Title:    
    Trustee

 
Address:
19811 4th Place
Escondido, CA 92029

 
MORGAN STANLEY DW INC. CUSTODIAN FOR IRA M. LECHNER (MSDW TAX ID #94-1671384)

 
By:
 
 
    /s/  IRA M. LECHNER      
  Name: Ira M. Lechner
  Title: Trustee

 
Address:
19811 4th Place
Escondido, CA 92029

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]


 
    
NEVINS MCBRIDE

 
Address:
 
     

 
 
 

 
ALFRED AND ADELE SALEH FAMILY TRUST

 
By:
 
 
   
  Name: Fred Saleh
  Title:    
   

 
Address:
14845 Caminito Lorren
Del Mar, CA 92014

 
    
LAWRENCE BIER

 
Address:
13 Blueberry Ridge Court
Rockville, MD 20854

 
DENNIS FAMILY TRUST DATED 3/29/93, EDWARD A. DENNIS, TRUSTEE, MARTHA G. DENNIS, TRUSTEE

 
By:
 
 
    /s/  EDWARD A. DENNIS,   
/s/  MARTHA G. DENNIS      
Edward A. Dennis and
Martha G. Dennis
Trustees

 
Address:
1921 Hypatia Way
La Jolla, CA 92037

 
/s/  ELLIOTT ROYSTON      
ELLIOTT ROYSTON

 
Address:
1634 Ponce de Leon Ave., #207
Atlanta, GA 30307

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]


 
    
DAVID W. ODMARK

 
Address:
 
     

 
 
 

 
INDOFIN, NV

 
By:
 
 
   
  Name: Pieter van Dongen
  Title: Director

 
Address:
c/o Avobone S.A.
9, Place du Bourg-de-Four
1204 Geneva
Switzerland
1204

 
    
HOWARD ALTMANN

 
Address:
P.O. Box 1965
New York, NY 10013

 
LOTUS BIOSCIENCE INVESTMENT HOLDINGS LIMITED

 
By:
 
 
   
  Name: Wong Ken Lum and
Mong Cheuk Wai
  Title: Directors

 
Address:
9th Floor, Central Building
Pedder Street, Hong Kong

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]


 
MERCER REVOCABLE FAMILY TRUST DTD 7/13/89

 
By:
 
 
   
  Name: Thomas Mercer
  Title: Trustee

 
Address:
P.O. Box 842
Rancho Santa Fe, CA 92067

 
WEIL FAMILY TRUST OF 1980,
CHRISTOPHER WEIL AND PATRICIA WEIL

 
By:
 
 
    /s/  CHRISTOPHER WEIL      
  Name: Christopher Weil
  Title: Trustee

 
Address:
12555 High Bluff Dr.
San Diego, CA 92130

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  GC&H INVESTMENTS

 
By:
 
 
    /s/  JOHN L. CARDOZA      
  Name: John L. Cardoza
  Title: Executive Partner

 
Address:
One Maritime Plaza
20th Floor
San Francisco, CA 94111

 
GC&H INVESTMENTS, LLC

 
By:
 
 
    /s/  JOHN L. CARDOZA      
  Name: John L. Cardoza
  Title: Executive Partner

 
Address:
One Maritime Plaza
20th Floor
San Francisco, CA 94111

 
GRAY GHOST, LLC

 
By:
 
 
    /s/  PHILIP GOELET      
  Name:    
    Philip Goelet
  Title: Manager

 
Address:
c/o Red Abbey, LLC
2330 West Joppa Road
Suite 330
Lutherville, MD 21093
  Fax: (410) 494-4247

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  HELLER FINANCIAL LEASING, INC.

 
By:
 
 
    /s/  MARK KING      
  Name: Mark King
  Title: Sr. Vice President

 
Address:
500 W. Monroe Street
Chicago, IL 60661
Attn: GE Technology Finance—Portfolio Management
  Fax: (312) 876-2593

 
PRIVATE EQUITY HOLDING-FAVRILLE, L.L.C.

 
By:
Howard Hughes Medical Institute
  Its: Sole Member and Manager

 
By:
 
 
    /s/  MARK A. BARNARD      
  Name:    
    Mark A. Barnard
  Title:    
    Managing Director

 
Address:
4000 Jones Bridge Road
Chevy Chase, MD 20815
  Fax: (301) 215-8691

 
SFP BIOTECH PARTNERS

 
By:
 
 
    /s/  STEVEN LEE YAMSHON      
Steven Lee Yamshon
Managing Partner

 
Address:
1851 E. First Street #150
Santa Ana, CA 92705

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  STEPHEN J. KANDEL SSB ROTH
CONVERSION IRA CUST.

 
By:
 
 
    /s/  STEPHEN J. KANDEL      
  Name: Stephen J. Kandel
  Title: Beneficial Owner

 
Address:
1021 Muirlands Drive
La Jolla, CA 92037

 
/s/  STEPHEN J. KANDEL      
STEPHEN AND GENEVIEVE KANDEL

 
Address:
P.O. Box 1891
Rancho Santa Fe, CA 92067

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  OAKWOOD MEDICAL MANAGEMENT IV (QP), L.L.C.

 
By:
Oakwood Medical Management IV, L.L.C.
  Its: Manager

 
By:
 
 
   
  Name: Raul E. Perez, M.D.
  Title: President

 
Address:
439 Kirkwood Road, Suite 208
St. Louis, Missouri 63122

 
 
 
 
  OAKWOOD MEDICAL INVESTORS IV, L.L.C.

 
By:
Oakwood Medical Management IV, L.L.C.
  Its: Manager

 
By:
 
 
   
  Name: Raul E. Perez, M.D.
  Title: President

 
Address:
439 Kirkwood Road, Suite 208
St. Louis, Missouri 63122

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  COMMUNITY INVESTMENT PARTNERS V L.P., LLLP

 
By:
CIP Management L.P., LLLP
  Its: Managing General Partner

 
By:
 
 
   
  Name: Daniel A. Burkhardt
  Title: Chairman of CIP Management, Inc., Managing General Partner of CIP Management L.P., LLLP

 
Address:
12555 Manchester Road
St. Louis, Missouri 63131

 
PIPER JAFFRAY HEALTHCARE FUND IV, L.P.

 
By:
Piper Jaffray Healthcare Management IV, LLC
  Its: General Partner

 
By:
 
 
    /s/  HEATH LUKATCH      
Heath Lukatch, Managing Director of Piper Jaffray Ventures Inc., its General Partner

 
Address:
100 Spear Street, Suite 1600
San Francisco, CA 94105
  Fax: (415) 979-9488

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  AVTECH PORTFOLIO, L.P.

 
By:
AVTech Ventures II, LLC
  Its: General Partner

 
By:
 
 
   
Gary L. Shields, Managing Member

 
Address:
1201 Camino Del Mar, Suite 215
Del Mar, CA 92014
  Fax: (858) 356-3563

 
MATTHEW C. & IRIS LYNN STRAUSS, CO-TRUSTEES OF STRAUSS FAMILY TRUST DTD. 6/5/92

 
By:
 
 
    /s/  MATTHEW STRAUSS      
  Name: Matthew C. Strauss
  Title Co-Trustee

 
Address:
c/o MC Strauss Company
990 Highland Drive, Suite 200
Solana Beach, CA 92075
  Fax: (858) 792-7834

 
BOSTON LIFE SCIENCE VENTURE CORP.

 
By:
 
 
    /s/  KENNETH LO      
  Name: Kenneth C.M. Lo
  Title: Chairman

 
Address:
5th Fl. No. 420
Fu-Hsin N. Road
Taipei, Taiwan

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]


 
THOMAS A. SHIFTAN AND MAUREEN E. SHIFTAN, CO-TRUSTEES OF SHIFTAN FAMILY TRUST DTD. 3/23/98

 
By:
 
 
    /s/  THOMAS SHIFTAN      
  Name: Thomas A. Shiftan
  Title Co-Trustee

 
Address:
7040 Neptune Place
La Jolla, CA 92037

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  NEEDHAM CAPITAL SBIC III, L.P.
NEEDHAM CAPITAL PARTNERS IIIA, L.P.
NEEDHAM CAPITAL PARTNERS III (BERMUDA), L.P.

 
By:
 
 
    /s/  JOHN J. PRIOR, JR.      
  Name:    
    John J. Prior, Jr.
  Title:    
    General Partner

 
Address:
Needham Asset Management
445 Park Avenue
New York, NY 10022

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]

  1998 CO-INVESTING LLC
EIN 43-1831139

 
By:
 
 
    /s/  JEFFREY MCDONNELL      
  Name: Jeff McDonnell
  Title Title Manager

 
Address:
1034 S. Brentwood, Suite 1860
St. Louise, MO 63117

 
SCHRODERS & CO. BANK SA

 
By:
 
 
    /s/  SAMUEL MOULIN      
  Name:    
    Samuel Moulin
  Title:    
    Director

 
Address:
8, Rue D'Italie
Geneve, Switzerland

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]


 
/s/  ERIC W. ROBERTS      
ERIC W. ROBERTS

 
Address:
205 E 78th St., #4H
New York, NY 10022

 
SCHEIBLER-LEHENY FAMILY LIVING TRUST U/D/T JUNE 6, 2001

 
By:
 
 
    /s/  EDWARD M. SCHEIBLER      

 
By:
 
 
    /s/  A. RACHEL LEHENY      

 
Names:
Edward G. Scheibler, Trustee
A. Rachel Leheny, Trustee

 
Address:
 
      P.O. Box 647

 
 
 
Rancho Santa Fe, CA 92067

 
 
 

 
THE NICHOLAS & PADDI ARTHUR TRUST DATED 4-14-98

 
By:
 
 
    /s/  NICHOLAS ARTHUR      

 
By:
 
 
    /s/  PADDI ARTHUR      

 
Names:
Nicholas Arthur, Co-Trustee
Paddi Arthur, Co-Trustee

 
Address:
 
     

 
 
 

 
 
 

[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]


SCHEDULE A

INVESTORS

INVESTOR

William Blair Capital Partners VII, L.P.

William Blair Capital Partners VII QP, L.P.

Alloy Partners 2000, L.P.

Alloy Ventures 2000, L.P.

Alloy Corporate 2000, L.P.

Alloy Investors 2000, L.P.

Alloy Annex I, L.P.

De Novo Ventures I, LP

De Novo (Q) Ventures I, LP

Sanderling Venture Partners V, L.P.

Sanderling V Biomedical, L.P.

Sanderling V Limited Partnership

Sanderling V Beteiligungs GmbH & Co. KG

Sanderling V Ventures Management

Sanderling Venture Partners V Co-Investment Fund, L.P.

Sanderling V Biomedical Co-Investment Fund, L.P.

Forward Ventures III Institutional Partners L.P.

Forward Ventures III L.P.

Forward Ventures IV B L.P.

Forward Ventures IV L.P.

Jacobs Investment Company, LLC

Stephen J. Kandel SSB Roth Conversion IRA Cust.

Sanden Kandel

EBR Holdings II Ltd.

Elliot Feuerstein

Michael M. Berns Living Trust Dated 10/16/90, Michael M. Berns, Trustee

The Payne Family Trust Dated 1/23/85, Errol G. Payne and Naomi F. Payne, Trustees

Joshua Cohen and Lita Cohen

Michael S. Grossman UBS IRA Rollover DG87091-68

Margaret Grossman UBS IRA DG44753

Guilio Wassmer

Christoph Dietsche


Warnke Broadley Kennedy Family Trust Dated 3/29/89, Joseph F. Kennedy, Trustee, Geriann Warnke, Trustee

Ira M. Lechner & Winifred Eileen Haag Family Trust Dated 1/21/00: Ira M. Lechner & Winifred Eileen Haag Trustees

Morgan Stanley DW Inc. Custodian for Ira M. Lechner (MSDW Tax ID #94-1671384)

Nevins McBride

Alfred and Adele Saleh Family Trust

Lawrence Bier

Dennis Family Trust Dated 3/29/93, Edward A. Dennis, Trustee, Martha G. Dennis, Trustee

Elliott Royston

David W. Odmark

Indofin, NV

Howard Altmann

Lotus Bioscience Investment Holdings Limited

Mercer Revocable Family Trust DTD 7/13/89

Weil Family Trust of 1980, Christopher Weil and Patricia Weil

GC&H Investments

GC&H Investments, LLC

Gray Ghost, LLC

Heller Financial Leasing, Inc.

SFP Biotech Partners

Schroders & Co. Bank SA

Antonio J. Grillo-Lopez and Maria S. Grillo Trustees Grillo-Marxuach Family Trust dated 6-28-95

Private Equity Holding-Favrille, L.L.C.

Stephen Kandel CGM Roth Conversion IRA CUST A/C #119-51879-17-380

Stephan and Genevieve Kandel

Oakwood Medical Investors IV (QP), L.L.C.

Oakwood Medical Investors IV, L.L.C.

Community Investment Partners V L.P., LLLP

Piper Jaffray Healthcare Fund IV, L.P.

AVTech Portfolio, L.P.

Matthew C. & Iris Strauss, co-trustees of Strauss Family Trust dtd. 6/5/92

Boston Life Science Venture Corp.

Thomas A. Shiftan and Maureen E. Shiftan, co-trustees of Shiftan Family Trust dated 3/23/98

[ADD NEW SERIES C INVESTORS]




QuickLinks

AMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
RECITALS
AGREEMENT
SCHEDULE A INVESTORS