-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 PM/fWNPs/vJchXpfoDsDMj7nKfDeU2tSJZjCtLYnM64pq24Z9QpzYm9R1ZIUjD0u
 Si2pc8RpXnq3KMwk2yndjA==

<SEC-DOCUMENT>0001225208-10-002032.txt : 20100121
<SEC-HEADER>0001225208-10-002032.hdr.sgml : 20100121
<ACCEPTANCE-DATETIME>20100121133614
ACCESSION NUMBER:		0001225208-10-002032
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100120
FILED AS OF DATE:		20100121
DATE AS OF CHANGE:		20100121

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			STEVENSON THOMAS C III
		CENTRAL INDEX KEY:			0001244556

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27702
		FILM NUMBER:		10538410

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BANK OF SOUTH CAROLINA CORP
		CENTRAL INDEX KEY:			0001007273
		STANDARD INDUSTRIAL CLASSIFICATION:	STATE COMMERCIAL BANKS [6022]
		IRS NUMBER:				571021355
		STATE OF INCORPORATION:			SC
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		256 MEETING ST
		STREET 2:		P O BOX 538
		CITY:			CHARLESTON
		STATE:			SC
		ZIP:			29402
		BUSINESS PHONE:		803 724 1500

	MAIL ADDRESS:	
		STREET 1:		256 MEETING STREET
		CITY:			CHARLESTON
		STATE:			SC
		ZIP:			29402
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-01-20</periodOfReport>

    <issuer>
        <issuerCik>0001007273</issuerCik>
        <issuerName>BANK OF SOUTH CAROLINA CORP</issuerName>
        <issuerTradingSymbol>BKSC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001244556</rptOwnerCik>
            <rptOwnerName>STEVENSON THOMAS C III</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>P. O. BOX 538</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>CHARLESTON</rptOwnerCity>
            <rptOwnerState>SC</rptOwnerState>
            <rptOwnerZipCode>29402-0538</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-01-20</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3255</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>9.8346</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>16317</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Unallocated Shares as a Trustee of ESOP</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>731</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks>Disclaims beneficial ownership of 199,323 shares owned by the BKSC ESOP which have been allocated to members of the plan, each of whom has the right to direct the Trustees as to the manner in which voting rights are to be exercised.</remarks>

    <ownerSignature>
        <signatureName>Janice B. Stanley, Attorney in Fact</signatureName>
        <signatureDate>2010-01-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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