Document Format Files
| Seq | Description | Document | Type | Size |
|---|---|---|---|---|
| 1 | FORM S-1 | d401292ds1.htm | S-1 | 2338091 |
| 2 | UNDERWRITING AGREEMENT | d401292dex11.htm | EX-1.1 | 168467 |
| 3 | FIFTH AMENDED & RESTATED CERTIFICATE OF INCORPORATION | d401292dex31.htm | EX-3.1 | 218722 |
| 4 | BYLAWS OF THE COMPANY | d401292dex32.htm | EX-3.2 | 49467 |
| 5 | FORM OF SERIES 1 NONCONVERTIBLE PREFERRED STOCK WARRANT | d401292dex42.htm | EX-4.2 | 31238 |
| 6 | COLLABORATIVE DEVELOPMENT & LICENSE AGREEMENT | d401292dex101.htm | EX-10.1 | 789205 |
| 7 | COLLABORATION & LICENSE AGREEMENT | d401292dex102.htm | EX-10.2 | 597421 |
| 8 | AGREEMENT WITH THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES | d401292dex103.htm | EX-10.3 | 375593 |
| 9 | THIRD AMENDED & RESTATED REGISTRATION RIGHTS AGREEMENT | d401292dex104.htm | EX-10.4 | 257657 |
| 10 | LEASE AGREEMENT BETWEEN ARE-500 ARSENAL STREET LLC | d401292dex106.htm | EX-10.6 | 647607 |
| 11 | AMENDED & RESTATED 1995 EQUITY INCENTIVE PLAN | d401292dex108.htm | EX-10.8 | 43782 |
| 12 | CONSENT OF PRICEWATERHOUSECOOPERS LLP | d401292dex231.htm | EX-23.1 | 1918 |
| 13 | ORIGINAL DRAFT REGISTRATION STATEMENT ON FORM S-1, DATED AUGUST 30, 2012 | d401292dex991.htm | EX-99.1 | 5352383 |
| 14 | AMENDMENT NO1 TO DRAFT REGISTRATION STATEMENT ON FORM S-1,DATED OCTOBER 10, 2012 | d401292dex992.htm | EX-99.2 | 2326520 |
| 16 | GRAPHIC | g401292g27h00.jpg | GRAPHIC | 83987 |
| 17 | GRAPHIC | g401292g89t09.jpg | GRAPHIC | 10614 |
| 18 | GRAPHIC | g401292g93f84.jpg | GRAPHIC | 54303 |
| 19 | GRAPHIC | g401292g94p71.jpg | GRAPHIC | 47414 |
| 20 | GRAPHIC | g401292img001.jpg | GRAPHIC | 25440 |
| 21 | GRAPHIC | g401292img002.jpg | GRAPHIC | 13690 |
| 22 | GRAPHIC | g401292img003.jpg | GRAPHIC | 9351 |
| 23 | GRAPHIC | g401306exd_pg042.jpg | GRAPHIC | 97639 |
| 24 | GRAPHIC | g401306exd_pg088.jpg | GRAPHIC | 31668 |
| 25 | GRAPHIC | g401306exd_pg089.jpg | GRAPHIC | 58383 |
| 26 | GRAPHIC | g401306exf_novartis.jpg | GRAPHIC | 2678 |
| 27 | GRAPHIC | g401306exf_pg62a.jpg | GRAPHIC | 103754 |
| 28 | GRAPHIC | g401306exf_pg62b.jpg | GRAPHIC | 10326 |
| 29 | GRAPHIC | g401306exf_pg69.jpg | GRAPHIC | 130039 |
| 30 | GRAPHIC | g401306g91t14.jpg | GRAPHIC | 262554 |
| 31 | GRAPHIC | g404889exd_pg042.jpg | GRAPHIC | 97639 |
| 32 | GRAPHIC | g404889exd_pg088.jpg | GRAPHIC | 31668 |
| 33 | GRAPHIC | g404889exd_pg089.jpg | GRAPHIC | 58383 |
| 34 | GRAPHIC | g404889exf_novartis.jpg | GRAPHIC | 2678 |
| 35 | GRAPHIC | g404889exf_pg62a.jpg | GRAPHIC | 103754 |
| 36 | GRAPHIC | g404889exf_pg62b.jpg | GRAPHIC | 10326 |
| 37 | GRAPHIC | g404889exf_pg69.jpg | GRAPHIC | 130039 |
| 38 | GRAPHIC | g404889g27h00.jpg | GRAPHIC | 89221 |
| 39 | GRAPHIC | g404889g89t09.jpg | GRAPHIC | 10614 |
| 40 | GRAPHIC | g404889g91t14.jpg | GRAPHIC | 262554 |
| 41 | GRAPHIC | g404889g93f84.jpg | GRAPHIC | 54303 |
| 42 | GRAPHIC | g404889g94p71.jpg | GRAPHIC | 47414 |
| 43 | GRAPHIC | g423523g27h00.jpg | GRAPHIC | 89221 |
| 44 | GRAPHIC | g423523g89t09.jpg | GRAPHIC | 10614 |
| 45 | GRAPHIC | g423523g93f84.jpg | GRAPHIC | 54303 |
| 46 | GRAPHIC | g423523g94p71.jpg | GRAPHIC | 47414 |
| 47 | filename47.htm | CORRESP | 17266 | |
| Complete submission text file | 0001193125-12-454422.txt | 16034469 |
IRS No.: 000000000 | State of Incorp.: DE | Fiscal Year End: 1231
Type: S-1 | Act: 33 | File No.: 333-184779 | Film No.: 121183196
SIC: 2834 Pharmaceutical Preparations
