VAN KAMPEN FUNDS INC.
24F-2 REPORT

U.S. SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 24F-2
ANNUAL NOTICE OF SECURITIES SOLD
PURSUANT TO RULE 24F-2



1. Name and address of issuer:

   Van Kampen Funds Inc.
   11 Greenway Plaza
   Houston, Texas 77046-1173

2. The name of each series or class of securities for which this form is filed:

   Van Kampen Focus Portfolios, Municipal Series 424

3. Investment company act file number:  811-2590
   Securities act file number:  333-103387

4(a).Last day of fiscal year for which this form is filed: FEBRUARY 28, 2011

4(b).[ ] Check box if this form is being filed late.

4(c).[ ] Check box if this is the last time the issuer will be filing this Form.

5.   Calculation of registration fee:
     (i)    Aggregate sale price of securities sold during
            the fiscal year pursuant to section 24(f):              $33,592

     (ii)   Aggregate price of securities redeemed or
            repurchased during the fiscal year:                     $33,592

     (iii)  Aggregate price of securities redeemed or repurchased
            during any prior fiscal year ending no earlier than
            October 11, 1995 that were not previously used to reduce
            registration fees payable to the Commission:            $0

     (iv)   Total available redemption credits
            [add items 5(ii) and 5 (iii)]:                          $33,592

     (v)    Net sales - if item 5(i) is greater than 5(iv)
            [subtract item 5(iv) from item 5(i)]:                   $0

     (vi)   Redemption credits available for use in future
            years - if item 5(i) is less than item 5(iv)
            subtract item 5(iv) from item 5(i)]:                    ($0)

     (vii)  Multiplier for determining registration fee
            (See instruction C.9):                                  x  0.0001161

     (viii) Registration  fee due [multiply  item 5(v)] by
            item 5(vii)] (enter 0 if no fee is due):                $0.00

6.   Prepaid Shares

     If the  response  to item 5(i) was  determined  by  deducting  an amount of
     securities that were  registered  under the Securities Act of 1933 pursuant
     to rule 24e-2 as in effect  before  (effective  date of  rescission of rule
     24e-2),  then  report the amount of  securities  (number of shares or other
     units  deducted  here: 0

     If there is a number of shares or other units that were registered pursuant
     to rule 24e-2 remaining unsold at the end of the fiscal year for which this
     form is filed that are  available for use by the issuer in future fiscal
     years, then state that number here: 0

7.   Interest  due - if this form is being filed more than 90 days after the end
     of the issuers fiscal year(see instruction D): $0

8.   Total of the amount of the registration fee due plus any interest due [line
     5(viii) plus line 7]: $0.00

9.   Date  the  registration  fee  and  any  interest  payment  was  sent to the
     Commissions lockbox depository:

     Method of Delivery:

     [ ]     Wire Transfer
     [ ]     Mail or other means



                                   SIGNATURES

      This report has been signed below by the following person on behalf of
      the issuer and in the capacity and on the date indicated.

                                             By Van Kampen Funds Inc., Depositor

                                                             By /s/ JOHN TIERNEY
                                                        ------------------------
                                                                    John Tierney
                                                              Executive Director

      May 25, 2011